Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Vitamin D deficiency is Associated with Increased Risk of Delirium and Mortality among Critically Ill, Elderly Covid-19 PatientsResearch article Published on 2022-11-012022-10-05 Journal: Complementary therapies in medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adjusted association baseline blood pressure collected data Comorbidities confounders coronavirus disease COVID-19 COVID-19 mortality COVID-19 patients Critically ill deficiency delirium demographic characteristics elderly Elderly patient Face mask higher risk Hospital admission Hospitalization Hospitalized ICU ICU admission Ill IMV incidence increase in Increased increased risk information intensive care Invasive mechanical ventilation Laboratory parameters less lower risk mechanical ventilation medications Mortality Older Organ failure outcome Patient positive prevalent propofol Prospective Study Result risk SARS-CoV-2 serum single center Study participants Treatment Vitamin D vitamin D deficiency vitamin D level vitamin D sufficiency was done were recorded [DOI] 10.1016/j.ctim.2022.102855 [Article Type] Research article
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020-21Article Published on 2022-11-012022-11-15 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Brazil clinical outcomes contribute COVID-19 COVID-19 patient Critically ill Critically ill patient cross-sectional cytokine Deceased dysregulated evaluated exhibited hospital IL-18 immune immune response Inflammation Inflammatory response Innate immunity innate immunity. intensive care laboratory data marker Older Patient patients with COVID-19 Platelet poor prognosis predict quantified significantly higher sociodemographic data with COVID-19 [DOI] 10.2217/fmb-2022-0057 PMC 바로가기
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab tocilizumab. treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기
Reliability and clinical correlations of semi-quantitative lung ultrasound on BLUE points in COVID-19 mechanically ventilated patients: The ‘BLUE-LUSS’-A feasibility clinical studyArticle Published on 2022-10-142022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] clinical study correlated correlation COVID-19 COVID-19 pandemic Critically ill Critically ill patient critically ill patients diagnostic feasibility ICUs independent indicated information intensive care intensive care unit Intervention lung Lung pathology mechanically ventilated P/F P/F ratio positive reduce Region reliability risk of infection RT-PCR SARS-CoV2 semi-quantitative significantly single-center the patient Treatment university Variability ventilated patient was performed were recorded [DOI] 10.1371/journal.pone.0276213 PMC 바로가기
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndromeArticle Published on 2022-10-142022-11-15 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] Analysis analysis antibody autoantibody autophagy gene Bioinformatics analysis Cell circadian clock Coagulation contribute COVID-19 COVID-19 patient COVID-19 patients Critically ill cytoHubba Cytoscape software dataset Differentially expressed genes evaluated expression Genes Genetic GSK3B identify Immune-mediated Immunotherapy increased risk Interference investigated Kyoto mechanism Mild Modification mononuclear cell ontology term pathway Patient patients protein-protein interaction Proteins regulate severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity suggested Symptom syndrome therapeutic potential thrombosis Transcriptome were used with COVID-19 [DOI] 10.1038/s41598-022-21694-3 PMC 바로가기
Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19Article Published on 2022-10-142023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] cardiac function ChIP Critically ill immune system. SARS-CoV-2 [DOI] 10.3389/fimmu.2022.968778 PMC 바로가기
Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19Article Published on 2022-10-122022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 28-day mortality adjusted odds ratio association clinical clinical condition clinical phenotype Critically ill Delta dose Factors France French humoral Immunocompromised Immunocompromised patient Infection information intensive care intensive care unit less mortality rate multicenter observé Occurrence omicron outcome Patient patients patients with COVID-19 phenotype prospective cohort study response to vaccination SARS-CoV-2 variant severe COVID-19 severe disease severity significantly higher Vaccine variant viral genome [DOI] 10.1038/s41467-022-33801-z PMC 바로가기
Adaptive immunity to SARS-CoV-2 infection: A systematic reviewArticle Published on 2022-10-102022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome adaptive Adaptive immunity addressed Alpha Antigen article B cell Biomarker case-control study caused CD4+ T cell CD8+ CD8+ T lymphocytes Cell cell types Characteristics clinical benefits Cohort studies coronavirus coronavirus disease Course COVID-19 Critically ill Critically ill patient cross-sectional CXCL9 Cytokines database disease English Evidence experimental evidence follicular HLA-DR humoral Humoral immunity IL-10 IL-13 IL-15 IL-17 IL-1α IL-2 IL-21 IL-22 IL-23 IL-4 IL-5 IL-7 immune system Immunity immunity. immunological Immunological memory immunopathological in vitro assays individuals inflammatory mediator involved leukocyte Ligand lymphocyte marker mild case Necrosis poor prognosis predominant produced programmed cell death progression Protein Regulatory T cell responsible SARS-CoV-2 SARS-COV-2 infection SciELO secretion severity Spanish subpopulation systematic review T helper T helper cell T lymphocyte T-cell Response Tfh TGF-β Th1 Th17 Th2 the antibody the disease TNF-α Treg tumor growth Vaccine variable [DOI] 10.3389/fimmu.2022.1001198 PMC 바로가기